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Ko et al., 2017), inhibiting the oncogenic transformation of normal cells through the regulation of relevant genes, tumor growth and development, angiogenesis and metastasis, downregulation of various oncogenic-related molecules and upregulation of tumor suppressor proteins, modulation of reactive oxygen species levels in cells to regulate cell proliferation, survival and apoptosis, and also transformation of the gut microbiota to acquire bioactivity-promoting properties to inhibit cancer development and progression (Anantharaju et al., 2016).Polyphenol combination therapy significantly improves anticancer efficacy and reduces drug resistance and chemotherapeutic toxicity through multi-target synergy

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247 Ferroptosis combined with ER stress is also associated with diabetic myocardial ischemia/reperfusion (I/R) injury